Journal Article

Genetic Diversity of Invasive Strains of <i>Haemophilus influenzae</i> Type b before and after Introduction of the Conjugate Vaccine in Italy

Marina Cerquetti, Rita Cardines, Maria Giufrè, Tonino Sofia, Fabio D'Ambrosio, Paola Mastrantonio and Marta Luisa Ciofi degli Atti

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 3, pages 317-319
Published in print August 2006 | ISSN: 1058-4838
Published online August 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/505499
Genetic Diversity of Invasive Strains of Haemophilus influenzae Type b before and after Introduction of the Conjugate Vaccine in Italy

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We determined the genotypes of 95 invasive Haemophilus influenzae type b (Hib) strains collected before and after introduction of widespread Hib vaccination in Italy. No substantial change in genetic diversity was highlighted by pulsed-field gel electrophoresis. However, an upward temporal trend in proportion of strains possessing multiple copies of the capsulation b locus was detected (P = .03).

Journal Article.  2102 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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