Journal Article

Single-Dose Lopinavir-Ritonavir Acutely Inhibits Insulin-Mediated Glucose Disposal in Healthy Volunteers

Grace A. Lee, Joan C. Lo, Francesca Aweeka, Jean-Marc Schwarz, Kathleen Mulligan, Morris Schambelan and Carl Grunfeld

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 5, pages 658-660
Published in print September 2006 | ISSN: 1058-4838
Published online September 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/505974
Single-Dose Lopinavir-Ritonavir Acutely Inhibits Insulin-Mediated Glucose Disposal in Healthy Volunteers

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Previously, we found that 4 weeks of treatment with lopinavir-ritonavir did not decrease insulin sensitivity but did increase adiponectin levels. In the present study, a single dose of lopinavir-ritonavir decreases insulin sensitivity but does not alter adiponectin levels. Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect.

Journal Article.  1927 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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