Journal Article

Association of Polymorphisms of <i>IGF1R</i> and Genes in the Transforming Growth Factor–β/Bone Morphogenetic Protein Pathway with Bacteremia in Sickle Cell Anemia

Adeboye H. Adewoye, Vikki G. Nolan, Qianli Ma, Clinton Baldwin, Diego F. Wyszynski, John J. Farrell, Lindsay A. Farrer and Martin H. Steinberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 5, pages 593-598
Published in print September 2006 | ISSN: 1058-4838
Published online September 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/506356
Association of Polymorphisms of IGF1R and Genes in the Transforming Growth Factor–β/Bone Morphogenetic Protein Pathway with Bacteremia in Sickle Cell Anemia

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Infection and bacteremia are common in sickle cell disease. We hypothesized that, consistent with evidence for the genetic modulation of other disease complications, the risk of developing bacteremia might also be genetically modulated. Accordingly, we studied the association of single nucleotide polymorphisms (SNPs) in candidate genes with the risk of bacteremia in sickle cell anemia. We found significant associations with SNPs in IGF1R and genes of the TGF-β/BMP pathway (BMP6, TGFBR3, BMPR1A, SMAD6 and SMAD3). We suggest that both IGF1R and the TGF-β/BMP pathway could play important roles in immune function in sickle cell anemia and their polymorphisms may help identify a “bacteremia-prone” phenotype.

Journal Article.  3337 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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