Journal Article

Acute Respiratory Distress Syndrome and Pneumonia: A Comprehensive Review of Clinical Data

Torsten T. Bauer, Santiago Ewig, Arne C. Rodloff and Eckhard E. Müller

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 6, pages 748-756
Published in print September 2006 | ISSN: 1058-4838
Published online September 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/506430
Acute Respiratory Distress Syndrome and Pneumonia: A Comprehensive Review of Clinical Data

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Acute respiratory distress syndrome (ARDS) and pneumonia are closely correlated in the critically ill patient. Whereas ARDS is often complicated by nosocomial pneumonia, pulmonary infection is also the most frequent single cause of ARDS. The prevalence of pneumonia during the course of ARDS seems to be particularly high, but whether persons with ARDS are more susceptible to pneumonia or simply have more risk factors remains unknown because of methodological limitations. Recent research suggests that host factors have a major bearing on the development of ARDS. To date, sepsis seems to be the principal link between pneumonia and ARDS. However, prospective observational data on this supposed sequence are not available. The individual role of specific pathogens for the development of ARDS is difficult to assess, because prospective studies are missing. Respiratory viruses have received particular attention, but this review suggests that infections with coronavirus and avian influenza virus (H5N1) are associated with a high incidence of ARDS.

Journal Article.  5327 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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