Journal Article

Childhood Cryptosporidiosis Is Associated with a Persistent Systemic Inflammatory Response

B. D. Kirkpatrick, Francine Noel, Patricia D. Rouzier, Jan L. Powell, J. W. Pape, Grylande Bois, W. Kemper Alston, Catherine J. Larsson, Katherine Tenney, Cassandra Ventrone, Cheryl Powden, Meera Sreenivasan and Cynthia L. Sears

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 5, pages 604-608
Published in print September 2006 | ISSN: 1058-4838
Published online September 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/506565
Childhood Cryptosporidiosis Is Associated with a Persistent Systemic Inflammatory Response

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Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.

Journal Article.  2989 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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