Journal Article

Human Milk Vacuolating Cytotoxin A Immunoglobulin A Antibodies Modify <i>Helicobacter pylori</i> Infection in Gambian Children

D. I. Campbell, J. E. G. Bunn, L. T. Weaver, M. Harding, W. A. Coward and J. E. Thomas

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 8, pages 1040-1042
Published in print October 2006 | ISSN: 1058-4838
Published online October 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/507524
Human Milk Vacuolating Cytotoxin A Immunoglobulin A Antibodies Modify Helicobacter pylori Infection in Gambian Children

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We collected data, including the weights, urea breath test results, and presence of maternal milk cytotoxin-associated gene-specific and vacuolating cytotoxin A-specific immunoglobulin A monthly from 48 mothers and infants (to 44 weeks of age) in The Gambia. In all, 11 children (23%) had negative urea breath test results, and 37 (77%) had positive results. Weight loss associated with Helicobacter pylori colonization was restricted to children whose mothers did not produce anti-vacuolating cytotoxin A antibodies in their milk (P =.028, by t test).

Journal Article.  2129 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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