Journal Article

Microarray Detection of Human Parainfluenzavirus 4 Infection Associated with Respiratory Failure in an Immunocompetent Adult

Charles Y. Chiu, Silvi Rouskin, Anita Koshy, Anatoly Urisman, Kael Fischer, Shigeo Yagi, David Schnurr, Paul B. Eckburg, Lucy S. Tompkins, Brian G. Blackburn, Jason D. Merker, Bruce K. Patterson, Don Ganem and Joseph L. DeRisi

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 8, pages e71-e76
Published in print October 2006 | ISSN: 1058-4838
Published online October 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/507896
Microarray Detection of Human Parainfluenzavirus 4 Infection Associated with Respiratory Failure in an Immunocompetent Adult

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A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.

Journal Article.  3504 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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