Journal Article

Coinfection with Hepatitis C Virus Increases Lymphocyte Apoptosis in HIV-Infected Patients

Marina Núñez, Vincent Soriano, Mariola López, Celia Ballesteros, Almudena Cascajero, Juan González-Lahoz and Jose Miguel Benito

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 9, pages 1209-1212
Published in print November 2006 | ISSN: 1058-4838
Published online November 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/508355
Coinfection with Hepatitis C Virus Increases Lymphocyte Apoptosis in HIV-Infected Patients

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To test the role of hepatitis C virus (HCV) in CD4 cell depletion in human immunodeficiency virus (HIV)–coinfected patients, T cell apoptosis was measured by annexin V labeling in 31 HIV-infected and 30 HIV-HCV–coinfected patients who were not receiving antiretroviral therapy. Apoptosis in naive CD4+ T cells and in naive and memory CD8+ T cells was significantly higher in HIV-HCV–coinfected than in monoinfected patients.

Journal Article.  2045 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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