Journal Article

Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell Response

Michele Barry, Adam V. Wisnewski, Michael A. Matthias, Sharon K. Inouye and Joseph M. Vinetz

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 43, issue 10, pages 1304-1307
Published in print November 2006 | ISSN: 1058-4838
Published online November 2006 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/508537
Suburban Leptospirosis: Atypical Lymphocytosis and γ-δ T Cell Response

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Leptospirosis is a zoonotic disease associated with a changing global epidemiology. Recently, an increased incidence of canine leptospirosis in the northeastern United States and Canada has been associated with increasing rates of infection among reservoir hosts, such as skunks, raccoons, and squirrels, that are common in suburban settings. We describe a case of leptospirosis that provides new insight into the epidemiology, diagnosis, and pathogenesis of this disease acquired in the suburban setting. Atypical lymphocytosis corresponded to an expansion of γ-δ T cells in peripheral blood.

Journal Article.  2491 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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