Journal Article

Selective Defect in Plasmacyoid Dendritic Cell Function in a Patient with AIDS-Associated Atypical Genital Herpes Simplex Vegetans Treated with Imiquimod

Lillian Abbo, Vladimir Vincek, Gordon Dickinson, Niraj Shrestha, Susanne Doblecki and Patrick A. J. Haslett

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 3, pages e25-e27
Published in print February 2007 | ISSN: 1058-4838
Published online February 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/510426
Selective Defect in Plasmacyoid Dendritic Cell Function in a Patient with AIDS-Associated Atypical Genital Herpes Simplex Vegetans Treated with Imiquimod

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We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon-α response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon-α may be overcome by stimulating intact alternative pathways.

Journal Article.  2026 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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