Journal Article

Rapid Detection and Identification of Bacterial Pathogens Using Novel Molecular Technologies: Infection Control and Beyond

Fred C. Tenover, L. Barth Reller and Melvin P. Weinstein

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 3, pages 418-423
Published in print February 2007 | ISSN: 1058-4838
Published online February 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/510684
Rapid Detection and Identification of Bacterial Pathogens Using Novel Molecular Technologies: Infection Control and Beyond

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The rapid detection and reporting of antimicrobial-resistant pathogens, such as methicillin-resistant Staphylococcus aureus vancomycin-resistant enterococci, and multidrug-resistant Mycobacterium tuberculosis is a challenge for the clinical microbiology laboratory. Molecular-based diagnostic tests can provide data on the presence of methicillin-resistant S. aureus in the nares in ∼ 1 h, whereas testing for the vanA and vanB resistance genes in enterococci isolated from perirectal samples can be completed in ∼ 4 h. Novel pyrosequencing assays can provide data regarding the presence of multidrug-resistant M. tuberculosis directly from positive mycobacterial broth cultures in <1 day. These data can assist physicians in both therapeutic and infection control decisions.

Journal Article.  3942 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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