Journal Article

Associations among Epstein-Barr Virus Subtypes, Human Leukocyte Antigen Class I Alleles, and the Development of Posttransplantation Lymphoproliferative Disorder in Bone Marrow Transplant Recipients

Irene Görzer, Elisabeth Puchhammer-Stöckl, Joost W. J. van Esser, Hubert G. M. Niesters and Jan J. Cornelissen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 5, pages 693-695
Published in print March 2007 | ISSN: 1058-4838
Published online March 2007 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/511647
Associations among Epstein-Barr Virus Subtypes, Human Leukocyte Antigen Class I Alleles, and the Development of Posttransplantation Lymphoproliferative Disorder in Bone Marrow Transplant Recipients

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The association between Epstein-Barr virus subtype, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder was examined in a group of 25 bone marrow transplant recipients. A highly statistically significant correlation was observed between the human leukocyte antigen B51 allele and development of posttransplantation lymphoproliferative disorder (P = .0016). This study provides, to our knowledge, the first evidence that the human leukocyte antigen B51 allele might predispose bone marrow transplant recipients to Epstein-Barr virus–associated posttransplantation lymphoproliferative disorder.

Journal Article.  2143 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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