Journal Article

Decrease in the Number of Reported Cases of Zygomycosis among Patients with Diabetes Mellitus: A Hypothesis

Dimitrios P. Kontoyiannis

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 8, pages 1089-1090
Published in print April 2007 | ISSN: 1058-4838
Published online April 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/512817
Decrease in the Number of Reported Cases of Zygomycosis among Patients with Diabetes Mellitus: A Hypothesis

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The number of reported cases of zygomycosis in patients with diabetes mellitus in developed countries has decreased since the 1990s, despite the rapid increase in the prevalence of diabetic patients in the Western world. Although prospective population-based studies need to better document this phenomenon, which may have a complex explanation, here I propose the hypothesis that widespread use of statins in patients with diabetes underlies such a trend. Statins have been shown to direct inhibitory activity against a range of Zygomycetes molds, both in vitro and in vivo.

Journal Article.  1039 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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