Journal Article

Acute Hepatitis with Severe Cholestasis and Prolonged Clinical Course Due to Hepatitis A Virus Ia and Ib Coinfection

Nicola Coppola, Domenico Genovese, Mariantonietta Pisaturo, Stefania Taffon, Claudio Argentini, Giuseppe Pasquale, Caterina Sagnelli, Felice Piccinino, Maria Rapicetta and Evangelista Sagnelli

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 9, pages e73-e77
Published in print May 2007 | ISSN: 1058-4838
Published online May 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513430
Acute Hepatitis with Severe Cholestasis and Prolonged Clinical Course Due to Hepatitis A Virus Ia and Ib Coinfection

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Background. Acute viral hepatitis due to hepatitis A virus is a self-limited illness that infrequently has a severe clinical course.

Methods. We analyzed the virological characteristics of acute hepatitis A in a patient with a severe clinical presentation (peak total and conjugated bilirubin levels, 65.5 mg/dL and 40.1 mg/dL, respectively) and a course of disease that lasted 7 months.

Results. Hepatitis A virus sequencing revealed coinfection with 2 subgenotypes of hepatitis A virus (Ia and Ib) as etiological factors of the illness.

Conclusions. Hepatitis A virus Ia and Ib coinfection may have accounted for the prolonged and severe course of illness.

Journal Article.  3231 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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