Journal Article

Evaluation of Polymerase Chain Reaction and Culture for Diagnosis of Pertussis in the Control of a County-Wide Outbreak Focused among Adolescents and Adults

Mark J. Sotir, Dianne L. Cappozzo, David M. Warshauer, Carol E. Schmidt, Timothy A. Monson, Jeffrey L. Berg, Jean A. Zastrow, Gerald W. Gabor and Jeffrey P. Davis

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 9, pages 1216-1219
Published in print May 2007 | ISSN: 1058-4838
Published online May 2007 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/513432
Evaluation of Polymerase Chain Reaction and Culture for Diagnosis of Pertussis in the Control of a County-Wide Outbreak Focused among Adolescents and Adults

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During a large pertussis outbreak, culture and polymerase chain reaction (PCR) were used to identify 149 case patients; of these case patients, 79 had positive PCR and culture results, 59 had positive PCR results and negative culture results, 11 had negative PCR results and positive culture results (10 PCR-negative, culture-positive specimens were collected ⩽14 days after illness onset). PCR and culture of samples obtained ⩽2 weeks after illness onset and PCR of samples obtained >2 weeks after illness onset proved to be most diagnostically useful.

Journal Article.  2197 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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