Journal Article

Treatment Outcomes Stratified by Baseline Immunological Status among Young Children Receiving Nonnucleoside Reverse-Transcriptase Inhibitor–Based Antiretroviral Therapy in Resource-Limited Settings

Daniel P. O'Brien, Delphine Sauvageot, David Olson, Myrto Schaeffer, Pierre Humblet, Mar Pudjades, Tom Ellman, Rony Zachariah, Elisabeth Szumilin, Line Arnould and Tony Read

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 9, pages 1245-1248
Published in print May 2007 | ISSN: 1058-4838
Published online May 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513433
Treatment Outcomes Stratified by Baseline Immunological Status among Young Children Receiving Nonnucleoside Reverse-Transcriptase Inhibitor–Based Antiretroviral Therapy in Resource-Limited Settings

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A study of 568 children aged <5 years who commenced nonnucleoside reverse-transcriptase inhibitor—based antiretroviral therapy in resource-limited settings revealed good early outcomes. After 12 months of antiretroviral therapy, survival probability was 0.89 (95% confidence interval, 0.86–0.92), with no significant difference among children stratified on the basis of baseline immunological levels; 62% attained a CD4 cell percentage >25%, and 7% continued to have a CD4 cell percentage <15%.

Journal Article.  2199 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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