Journal Article

Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis

Dominique Gendrel, Josette Raymond, Marcel Assicot, Florence Moulin, Jean-Luc Iniguez, Pierre Lebon and Claude Bohuon

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 24, issue 6, pages 1240-1242
Published in print June 1997 | ISSN: 1058-4838
Published online June 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513633
Measurement of Procalcitonin Levels in Children with Bacterial or Viral Meningitis

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We measured the plasma procalcitonin levels in 59 children who were admitted to the hospital because of bacterial or viral meningitis. Eighteen children with acute bacterial meningitis had elevated procalcitonin levels (mean level, 54.5 µg/L; range, 4.8–110 µg/L). The procalcitonin levels in 41 children with viral meningitis were low (mean level, 0.32 µg/L; range, 0–1.7 µg/L; P < .0001). Assay of cerebrospinal fluid (CSF) cells and proteins and serum C-reactive protein showed a zone of overlapping values between the two groups. Procalcitonin was not produced in CSF. Plasma procalcitonin levels decreased rapidly during antibiotic therapy. These data suggest that the measurement of plasma procalcitonin might be of value in the differential diagnosis of meningitis due to either bacteria or viruses.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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