Journal Article

Systemic Infection with <i>Mycobacterium genavense</i> Following Immunosuppressive Therapy in a Patient Who Was Seronegative for Human Immunodeficiency Virus

Christian Bogdan, Peter Kern, Elvira Richter, Andrea Tannapfel, Sabine Rüsch-Gerdes, Thomas Kirchner and Werner Solbach

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 24, issue 6, pages 1245-1247
Published in print June 1997 | ISSN: 1058-4838
Published online June 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513634
Systemic Infection with Mycobacterium genavense Following Immunosuppressive Therapy in a Patient Who Was Seronegative for Human Immunodeficiency Virus

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We describe, to our knowledge, the first case of disseminated Mycobacterium genavense infection in a patient who was seronegative for human immunodeficiency virus. The patient, a 47-year-old woman, had been previously treated with immunosuppressive drugs for 9 months to control an unclassified immunologic disorder characterized by intermittent fever and inflammatory pulmonary, hepatic, and dermal infiltrates. Antemortem and postmortem examinations revealed the presence of numerous mycobacteria in the bone marrow, spleen, kidneys, and lungs; these organisms failed to grow in vitro and were identified as M. genavense by 16S rRNA gene sequencing. This case illustrates that systemic M. genavense infections are not restricted to patients with AIDS but can also occur in otherwise immunocompromised patients.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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