Journal Article

Focal Infections Due to Non-<i>typhi Salmonella</i> in Patients with AIDS: Report of 10 Cases and Review

Fernández Guerrero Manuel L., José M. Ramos, Antonio Núñez, Manuel Cuenca and Miguel de Górgolas

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 3, pages 690-697
Published in print September 1997 | ISSN: 1058-4838
Published online September 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513747
Focal Infections Due to Non-typhi Salmonella in Patients with AIDS: Report of 10 Cases and Review

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Bacteremia due to non-typhi Salmonella is frequent in human immunodeficiency virus (HIV)- infected patients; however, focal complications rarely have been reported. Ten of 38 HIV-infected patients (26.3%) with salmonellosis documented over a period of 9 years had focal suppurative complications; only 19 (3.9%) of 490 adults without HIV infection who were seen during the same period had focal complications (P = .001). Infections of the urinary tract, lungs, and soft tissue, followed by arthritis, endocarditis, and meningitis were most frequently seen. Although salmonellosis occasionally heralded HIV infection, most patients were severely immunocompromised and had CD4 cell counts of <100/mm3. The mortality rate was 50%, equivalent to that observed among patients with other immunosuppressive disorders (52.6%). Major emphasis must be put on intensive therapy for salmonella bacteremia and prevention of its complications.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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