Journal Article

Immune Response to Simulated Postexposure Rabies Booster Vaccinations in Volunteers Who Received Preexposure Vaccinations

Chartchai Kositprapa, Kornvika Limsuwun, Henry Wilde, Wipaporn Jaijaroensup, Apinya Saikasem, Pakamatz Khawplod, Upsorn Kri-aksorn and Chalida Supich

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 3, pages 614-616
Published in print September 1997 | ISSN: 1058-4838
Published online September 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513760
Immune Response to Simulated Postexposure Rabies Booster Vaccinations in Volunteers Who Received Preexposure Vaccinations

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Several studies of the efficacy of intradermal postexposure rabies vaccination have shown that this procedure is safe, effective, and cost saving. Less is known about the reliability of the present World Health Organization (WHO)—approved intradermal preexposure regimen, which consists of three 0.1-mL doses that are generally given on days 0, 7, and 28. Previous studies have shown that neutralizing antibody responses are lower and of shorter duration in subjects given the reduceddose intradermal regimen. Thus, it is still uncertain whether the WHO-recommended single intramuscular or intradermal booster injections given on days 0 and 3 would prevent death in all cases. In this preliminary study, we evaluated titers of neutralizing antibody in Thai student volunteers given two simulated postexposure boosters, as recommended by WHO, and we compared these volunteers to a group given vaccine intramuscularly. We observed a lower, although adequate, accelerated immune response in those given the preexposure series and postexposure boosters intradermally.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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