Journal Article

Hepatitis B Virus DNA in Persons with Isolated Antibody to Hepatitis B Core Antigen Who Subsequently Received Hepatitis B Vaccine

A. Eduardo Silva, Brian J. McMahon, Alan J. Parkinson, Maria H. Sjogren, Jay H. Hoofnagle and Adrian M. Di Bisceglie

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 4, pages 895-897
Published in print April 1998 | ISSN: 1058-4838
Published online April 1998 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/513918
Hepatitis B Virus DNA in Persons with Isolated Antibody to Hepatitis B Core Antigen Who Subsequently Received Hepatitis B Vaccine

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Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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