Journal Article

Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange

Marcel van Deuren, Johan T. M. Frieling, Johanna van der Ven Jongekrijg, Chris Neeleman, Frans G. M. Russel, Henk J. J. van Lier, Anton K. M. Bartelink and Jos W. M. van der Meer

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 4, pages 918-923
Published in print April 1998 | ISSN: 1058-4838
Published online April 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/513933
Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange

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In 39 patients with acute meningococcal infections, the plasma concentrations of tumor necrosis factor-α (TNF) and its soluble receptors (sRs) TNFsR-p55 and TNFsR-p75 were measured from admission till recovery. At admission, patients with shock had significantly higher TNF, TNFsR-p55, and TNFsR-p75 values than patients without shock. In addition, during the first 24 hours, patients with shock had higher TNFsR-p75 to TNFsR-p55 ratios, indicating that in shock the increase of TNFsR-p75 exceeds that of TNFsR-p55. TNF measured more than 12 hours after admission failed to differentiate between shock and nonshock because TNF concentrations normalized within 12–24 hours. However, because concentrations of TNFsRs remained elevated for 5–6 days, at that time plasma TNFsRs still differentiated between shock and nonshock. Plasma exchange or whole blood exchange (PEBE), performed in 20 patients with shock, accelerated the decrease of plasma TNFsRs. However, because of a rebound after each PEBE session, the overall half-lives of both TNFsRs were not affected by PEBE.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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