Journal Article

Immunity to Pertussis 5 Years after Booster Immunization during Adolescence

Kati Edelman, Qiushui He, Johanna Mäkinen, Anna Sahlberg, Marjo Haanperä, Lode Schuerman, Joanne Wolter and Jussi Mertsola

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 44, issue 10, pages 1271-1277
Published in print May 2007 | ISSN: 1058-4838
Published online May 2007 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514338
Immunity to Pertussis 5 Years after Booster Immunization during Adolescence

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  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

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Background.We conducted a 5-year follow-up study on the persistence of pertussis-specific antibody and cell-mediated immunity after booster immunization of adolescents aged 11–13 years with a tricomponent acellular pertussis vaccine (Boostrix; trials diphtheria-tetanus–acellular pertussis [Tdap]–004/030).

Methods.Cellular and humoral immunity to pertussis toxin (PT), filamentous hemagglutinin, and pertactin were measured in adolescents (age, 16 years) 5 years after booster immunization. Similar investigations were performed for control adolescents who had received only diphtheria and tetanus booster vaccination.

Results.Five years after pertussis booster vaccination, the geometric mean concentrations of immunoglobulin G (IgG) elicited by each of the 3 pertussis vaccine antigens decreased from 1-month and 3-year postvaccination levels, but with the exception of PT IgG, were still higher than the prevaccination levels. PT IgG levels were undetectable in 28% of the subjects, but 44% of those subjects still tested positive for cell-mediated immunity to PT. Filamentous hemagglutinin IgG and pertactin IgG levels were significantly higher in Tdap-boosted adolescents than in the control subjects. Antibody concentrations at 1 month after vaccination strongly predicted antibody persistence. Cell-mediated immunity levels to PT, filamentous hemagglutinin, and pertactin persisted above the prebooster levels measured 5 years earlier.

Conclusions.The results of the present study of adolescents indicate that the interval between acellular pertussis booster immunizations might be extended beyond 5 years.

Journal Article.  4624 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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