Journal Article

Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women

Heidi S. Smith, James P. Hughes, Thomas M. Hooton, Pacita Roberts, Delia Scholes, Andy Stergachis, Ann Stapleton and Walter E. Stamm

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 1, pages 63-68
Published in print July 1997 | ISSN: 1058-4838
Published online July 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514502
Antecedent Antimicrobial Use Increases the Risk of Uncomplicated Cystitis in Young Women

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To examine whether antecedent antimicrobial use influenced subsequent relative risk of urinary tract infection (UTI) in premenopausal women, data were analyzed from two cohorts of women observed prospectively for 6 months to determine risk factors for UTI. Using a Cox proportional hazards model to adjust for covariates, we found that 326 women in a University cohort and 425 women in a health-maintenance organization cohort were at increased risks for UTI (2.57 [95% confidence interval (CI), 1.24–5.32] and 5.83 [95% CI, 3.17–10.70], respectively) if antimicrobials had been taken during the previous 15–28 days but not during the previous 3, 7, or 14 days. The increased risks were noted both for women whose antimicrobial use was for treatment of a previous UTI and for women who received antimicrobials for other illnesses. These results suggest that recent antimicrobial use increases a woman's risk of UTI, perhaps by altering the indigenous urogenital flora and predisposing to vaginal colonization with uropathogens.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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