Journal Article

International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections

John E. Edwards, Gerald P. Bodey, Raleigh A. Bowden, Thomas Büchner, Ben E. de Pauw, Scott G. Filler, Mahmoud A. Ghannoum, Michel Glauser, Raoul Herbrecht, Carol A. Kauffman, Shigeru Kohno, Pietro Martino, Françoise Meunier, Takeshi Mori, Michael A. Pfaller, John H. Rex, Thomas R. Rogers, Robert H. Rubin, Joseph Solomkin, Claudio Viscoli, Thomas J. Walsh and Mary White

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 1, pages 43-59
Published in print July 1997 | ISSN: 1058-4838
Published online July 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514504
International Conference for the Development of a Consensus on the Management and Prevention of Severe Candidal Infections

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Because of the rapidly increasing incidence of serious candidal infections, a consensus conference of 22 investigators from the United States, Europe, and Japan was held to discuss strategies for the prevention and treatment of deep-organ infections caused by Candida species. Commonly asked questions concerning the management of candidal infections were selected for discussion by the participating investigators. Possible answers to the questions were developed by the investigators, who then voted anonymously for their preferences. In certain instances, unanimity or a strong consensus was the result. In all cases, the full spectrum of responses was recorded and is presented in this report. The forms of candidal infection addressed included candidemia, candiduria, hepatosplenic candidiasis (chronic systemic candidiasis), candidal endophthalmitis, and candidal peritonitis. Prevention and treatment strategies were considered for patients who have undergone surgery, for neutropenic and nonneutropenic patients, and for patients who have undergone bone marrow and solid organ transplantation. The therapeutic roles of amphotericin B (standard and lipid formulations) and the azoles were considered.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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