Journal Article

Central Nervous System Pneumocystosis in a Patient with AIDS

John A. Bartlett and Christine Hulette

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 1, pages 82-85
Published in print July 1997 | ISSN: 1058-4838
Published online July 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514519
Central Nervous System Pneumocystosis in a Patient with AIDS

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Extrapulmonary involvement with Pneumocystis carinii has been described in 0.5%*#x2013;2.5% of persons with AIDS. One hundred nine patients with AIDS and confirmed extrapulmonary pneumocystosis were identified, and seven of these patients (including our patient) had central nervous system (CNS) pneumocystosis. Of these seven patients, six had prior AIDS-related complications, and three had previous P. carinii pneumonia. Six patients had CNS symptoms, one of whom underwent a focal neurological examination. No cases were diagnosed before death. The involved sites were the cerebral cortex (2 patients), meninges (2), pituitary gland (1), putamen (1), and nonspecified locations (3). In two patients, organisms were seen around blood vessels, and in five patients there was concurrent neuropathology. In summary, CNS involvement with P. carinii usually occurs as a late complication of AIDS and probably represents hematogenous dissemination.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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