Journal Article

Resistance Patterns of <i>Streptococcus pneumoniae</i> from Carriers Attending Day-Care Centers in Southwestern Greece

George A. Syrogiannopoulos, Ioanna N. Grivea, Nicholas G. Beratis, Adamantia E. Spiliopoulou, Elizabeth L. Fasola, Saralee Bajaksouzian, Peter C. Appelbaum and Michael R. Jacobs

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 2, pages 188-194
Published in print August 1997 | ISSN: 1058-4838
Published online August 1997 | e-ISSN: 1537-6591 | DOI:
Resistance Patterns of Streptococcus pneumoniae from Carriers Attending Day-Care Centers in Southwestern Greece

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The resistance to β-lactam and non-β-lactam antibiotics of 133 nasopharyngeal isolates of Streptococcus pneumoniae recovered from December 1995 to February 1996 from children attending seven day-care centers in southwestern Greece was studied. Reduced susceptibility to one or more antimicrobial agents was found in 70 isolates (53%), as follows: penicillin, 17% intermediate, 12% resistant; cefotaxime, 10.5% intermediate, 1.5% resistant; trimethoprim-sulfamethoxazole, 8% intermediate, 35% resistant; chloramphenicol, 27% resistant; tetracycline, 29% resistant; and erythromycin/ clindamycin, 19% resistant. Eighty-seven percent of penicillin-intermediate or -resistant strains belonged to serogroups/serotypes 19, 21, and 23. Fifty-six percent of the antibiotic-resistant pneumococci were multiply resistant, including serogroup 6 strains that were penicillin-susceptible but resistant to all non-β-lactam drugs tested, as well as serogroup 23 strains resistant to penicillin, chloramphenicol, tetracycline, and trimethoprim-sulfamethoxazole. The high incidence of antibiotic-resistant pneumococci and the divergent and unique resistance patterns found in this study underline the need for global surveillance of S. pneumoniae to document the evolution and spread of resistant strains and to guide therapy.

Journal Article.  0 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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