Journal Article

Effects of Requiring Prior Authorization for Selected Antimicrobials: Expenditures, Susceptibilities, and Clinical Outcomes

A. Clinton White, Robert L. Atmar, Joan Wilson, Thomas R. Cate, Charles E. Stager and Stephen B. Greenberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 25, issue 2, pages 230-239
Published in print August 1997 | ISSN: 1058-4838
Published online August 1997 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514545
Effects of Requiring Prior Authorization for Selected Antimicrobials: Expenditures, Susceptibilities, and Clinical Outcomes

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Antimicrobial control programs are widely used to decrease drug expenditures, but effects on antimicrobial resistance and outcomes for patients are unknown. When a requirement for prior authorization for selected parenteral antimicrobial agents was initiated at our urban, county teaching hospital, total parenteral antimicrobial expenditures decreased by 32%. Susceptibilities to all β-lactam and quinolone antibiotics increased, with dramatic increased susceptibilities in isolates recovered in intensive care units, increased susceptibilities in isolates recovered in other inpatient sites, and little change in susceptibilities in isolates recovered in outpatient sites despite no change in infection control practices. For patients with bacteremia due to gram-negative organisms, overall survival did not change with restrictions. No differences occurred in the median time from initial positive blood culture to receipt of an appropriate antibiotic or in the median time from positive blood culture to discharge from the hospital. Thus, requiring preapproval for selected parenteral agents can decrease antimicrobial expenditures and improve susceptibilities to antibiotics without compromising patient outcomes or length of hospital stay.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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