Journal Article

Low Plasma Levels of Adrenocorticotropic Hormone in Patients with Acute Influenza

William McK. Jefferies, James C. Turner, Monica Lobo and Jack M. Gwaltney

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 3, pages 708-710
Published in print March 1998 | ISSN: 1058-4838
Published online March 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514594
Low Plasma Levels of Adrenocorticotropic Hormone in Patients with Acute Influenza

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Plasma levels of adrenocorticotropic hormone (ACTH) and cortisol were measured in young adults with influenza virus type A (H3N2) infection for whom cultures were positive and in comparable controls without symptoms or other evidence of illness. The mean plasma ACTH level ± SE in 19 patients with acute influenza was 13.5 ± 2.1 pg/mL compared with 23 ± 3.2 pg/mL in 11 controls (P = .02). Mean plasma ACTH levels ± SE had risen to 21 ± 4.1 pg/mL in specimens obtained from patients during convalescence. The mean plasma cortisol level ± SE in patients with acute influenza was 13.7 ± 1.4 μg/dL compared with 10.8 ± 1.0 μg/dL in controls (P = not significant). ACTH levels in individual controls were relatively higher than their cortisol levels, but ACTH levels in patients tended to be lower than cortisol levels in paired specimens. These findings suggest that influenza virus type A infection may have an inhibitory effect on the production or release of ACTH.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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