Journal Article

Shedding of Cytomegalovirus and Herpesviruses 6, 7, and 8 in Saliva of Human Immunodeficiency Virus Type 1—Infected Patients and Healthy Controls

Erik Lucht, Maria Brytting, Lotte Bjerregaard, Inger Julander and Annika Linde

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 1, pages 137-141
Published in print July 1998 | ISSN: 1058-4838
Published online July 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514604
Shedding of Cytomegalovirus and Herpesviruses 6, 7, and 8 in Saliva of Human Immunodeficiency Virus Type 1—Infected Patients and Healthy Controls

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We used the polymerase chain reaction to study the presence of DNA from cytomegalovirus (CMV) and human herpesvirus (HHV)-6, HHV-7, and HHV-8 in saliva from 44 human immunodeficiency virus (HIV) type 1–infected patients at different stages of disease and in 15 healthy HIV-seronegative controls. CMV DNA, HHV-6 DNA, and HHV-7 DNA were found in all groups, but HHV-8 DNA was found only in symptomatic HIV-1-infected patients (5 [17%] of 29). One of the patients with HHV-8 DNA in saliva had oral Kaposi's sarcoma at the time of sampling, and another later developed the tumor. CMV DNA was found most often in the patients with AIDS. HHV-6 shedding tended to be less frequent among HIV-1-infected patients than among healthy controls. HHV-7 DNA was detected least frequently in the group of patients with AIDS. The presence of viral DNA was not correlated either with antiherpesvirus drug therapy or with oral symptoms, apart from Kaposi's sarcoma.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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