Journal Article

Varicella-Zoster Virus Infection Associated with Acute Liver Failure

Hilde Dits, Eric Frans, Alexander Wilmer, Marc Van Ranst, Johan Fevery and Herman Bobbaers

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 1, pages 209-210
Published in print July 1998 | ISSN: 1058-4838
Published online July 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514613
Varicella-Zoster Virus Infection Associated with Acute Liver Failure

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Although acute liver failure due to the varicella-zoster virus is rare, it is frequently fatal. Immunologic impairment is a significant predisposing factor. Classic symptoms at presentation are rash, abdominal pain, and fever. After some days patients go on to develop full-blown liver failure. The diagnosis can be confirmed by histological examination and electron microscopy with fluorescent staining, immunohistochemistry, and in situ hybridization of the liver. In cases of high suspicion, acyclovir therapy should not be delayed.s

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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