Journal Article

The Pharmacodynamics of Aminoglycosides

Melinda K. Lacy, David P. Nicolau, Charles H. Nightingale and Richard Quintiliani

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 1, pages 23-27
Published in print July 1998 | ISSN: 1058-4838
Published online July 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514620
The Pharmacodynamics of Aminoglycosides

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Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily aminoglycoside dosing regimens. This new approach to aminoglycoside dosing appears to be safe, efficacious, and cost-effective, resulting in its increasing popularity in clinical practice.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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