Journal Article

Economic Evaluation of Rotavirus Vaccinations in Finland: Randomized, Double-Blind, Placebo-Controlled Trial of Tetravalent Rhesus Rotavirus Vaccine

Aino K. Takala, Eeva Koskenniemi, Jaana Joensuu, Marjukka Mäkelä and Timo Vesikari

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 2, pages 272-282
Published in print August 1998 | ISSN: 1058-4838
Published online August 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514650
Economic Evaluation of Rotavirus Vaccinations in Finland: Randomized, Double-Blind, Placebo-Controlled Trial of Tetravalent Rhesus Rotavirus Vaccine

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The cost-benefit ratio of tetravalent rhesus rotavirus vaccine (RRV-TV) in Finland for prevention of rotavirus gastroenteritis was assessed in a randomized, double-blind, placebo-controlled trial. Costs related to vaccination, side effects, and gastroenteritis were identified. Children received RRV-TV (n = 1,191) or placebo (n = 1,207) at 2, 3, and 5 months of age with other infant vaccinations. Prospective follow-up averaged 1.0 years per child. An intention-to-treat analysis was performed from the perspective of society. Nine cases of severe rotavirus gastroenteritis occurred in the RRV-TV group, versus 100 in the placebo group (P < .0001); mean cost per vaccinated child was 4 Finnish marks (FIM) in the RRV-TV group, versus 203 FIM in the placebo group. Side effects with related costs occurred after 11% and 7% of doses in the RRV-TV group and placebo group, respectively (P < .001); mean cost per child was 89 FIM vs. 75 FIM. The break-even cost (i.e., net benefit, excluding cost of vaccine) of RRV-TV in prevention of severe rotavirus gastroenteritis was 109 FIM (U.S. $19.60) per child.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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