Journal Article

Decline in Rates of Seropositivity for Measles, Mumps, and Rubella Antibodies Among Previously Immunized Children Treated for Acute Leukemia

S. Feldman, M. Andrew, M. Norris, B. McIntyre and R. Iyer

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 2, pages 388-390
Published in print August 1998 | ISSN: 1058-4838
Published online August 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514661
Decline in Rates of Seropositivity for Measles, Mumps, and Rubella Antibodies Among Previously Immunized Children Treated for Acute Leukemia

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We prospectively determined the measles-mumps-rubella (MMR) antibody status of 39 previously vaccinated children before and after administering protocol-directed chemotherapy for acute leukemia. At diagnosis the seropositivity rates for measles and mumps—specific immunoglobulin G were ⩾90%, while the seropositivity rate for rubella was 85%. After treatment, rates of seropositivity for measles antibody declined by 13% (90% of patients to 77%; P = .13); for mumps antibody, by 18% (97%–79%; P = .02); and for rubella antibody, by 21% (85%–64%; P = .03). These findings suggest that some survivors of acute leukemia during childhood have an increased susceptibility to MMR viruses and would benefit from posttreatment evaluation of their immune statuses and from possible revaccination.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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