Journal Article

Use of Hepatitis A Vaccine in a Community-Wide Outbreak of Hepatitis A

Allen S. Craig, Denise C. Sockwell, William Schaffner, William L. Moore, Jena T. Skinner, Ian T. Williams, Frederic E. Shaw, Craig N. Shapiro and Beth P. Bell

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 3, pages 531-535
Published in print September 1998 | ISSN: 1058-4838
Published online September 1998 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/514700
Use of Hepatitis A Vaccine in a Community-Wide Outbreak of Hepatitis A

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Hepatitis A outbreaks in communities are often difficult to control. From July 1994 through June 1995, 676 cases of hepatitis A were reported in Shelby County, Tennessee. With the licensure of a hepatitis A vaccine in February 1995, a new tool for outbreak control became available. During August–October 1995, a mass vaccination campaign was conducted. A total of 34,054 children received the first dose of hepatitis A vaccine. From December 1995 through December 1996, the number of hepatitis A cases reported inside the intervention area declined by 64%; outside the intervention area, the number of cases declined by 40%. The precise contribution of the vaccine campaign to the decline in the number of outbreak cases is difficult to quantify because community outbreaks often wane over time. The vaccine campaign may have hastened the decline of the number of outbreak cases. Future interventions should consider an earlier campaign with greater vaccine coverage.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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