Journal Article

Predictors and Outcome of Admission for Invasive <i>Streptococcus pneumoniae</i> Infections at a Canadian Children's Hospital

Kevin B. Laupland, H. Dele Davies, James D. Kellner, Nina-Lynn Luzod, Tulika Karan, Doreen Ma, Dina Taub, Cheri Nijssen-Jordan, Gary Katzko, Taj Jadavji and Deirdre Church

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 3, pages 597-602
Published in print September 1998 | ISSN: 1058-4838
Published online September 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514707
Predictors and Outcome of Admission for Invasive Streptococcus pneumoniae Infections at a Canadian Children's Hospital

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Rates of admission for invasive Streptococcus pneumoniae infection in children vary considerably between institutions. We performed a retrospective study to investigate factors used in the decision to admit patients with invasive S. pneumoniae infection to Alberta Children's Hospital. Of 254 patients who were initially assessed in the emergency department, 38.2% were admitted to the hospital. Significant risk factors for admission as determined by a logistic regression model included murmur (odds ratio [OR], 18.98; 95% confidence interval [CI], 4.08–88.23), focal infection (OR, 11.41; 95% CI, 5.07–25.67), and older age (OR, 2.72; 95% CI, 1.03–7.17). Higher hemoglobin level (OR, 0.96; 95% CI, 0.93–0.99) and temperature of >38.5°C (OR, 0.39; 95% CI, 0.18–0.85) were associated with a lower risk of admission. Two patients died (case-fatality rate, 0.7%). Despite the low rate of admission for invasive S. pneumoniae infections at our hospital, the mortality rate was comparable with those at institutions with higher rates of admission, thus suggesting that the factors we identified may be useful in deciding whether to admit patients with (or who are at high risk for) invasive S. pneumoniae infections.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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