Journal Article

Comparative Study of Mortality and Morbidity in Premature Infants (Birth Weight, <1,250 g) with Candidemia or Candidal Meningitis

Bonita E. Lee, Po-Yin Cheung, Joan L. Robinson, Christene Evanochko and Charlene M. T. Robertson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 3, pages 559-565
Published in print September 1998 | ISSN: 1058-4838
Published online September 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514712
Comparative Study of Mortality and Morbidity in Premature Infants (Birth Weight, <1,250 g) with Candidemia or Candidal Meningitis

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Little information is available on long-term neurodevelopment of premature neonates with invasive candidal infections. We retrospectively studied the outcomes for 25 premature neonates (birth weight, <1,250 g) with candidemia or candidal meningitis (cases) and compared them with 25 neonates matched for birth weight (±100 g) and gestational age (±1 week) (controls). Durations of antibiotic therapy, artificial ventilation, invasive catheterizations, and hyperalimentation were longer for cases than for controls. Cases had a higher final grade of intraventricular hemorrhage than did controls (median: 3.0 vs. 2.5, respectively; P < .05). Forty-four percent (11 of 25) of cases and 16% (4 of 25) of controls died (P > .05), and 29% (4 of 14) of surviving cases and 14% (3 of 21) of controls were disabled (P > .05). More cases had combined mortality and neurodevelopmental disabilities than did controls (60% vs. 28%, respectively; P < .05). Use of invasive therapies should be minimized for premature neonates at risk for invasive candidal infection that is associated with adverse outcomes.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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