Journal Article

Spread of Drug-Resistant <i>Streptococcus pneumoniae</i> in Asian Countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

Jae-Hoon Song, Nam Yong Lee, Satoshi Ichiyama, Ryoji Yoshida, Yoichi Hirakata, Wang Fu, Anan Chongthaleong, Nalinee Aswapokee, Cheng-Hsun Chiu, M. K. Lalitha, Kurien Thomas, Jennifer Perera, Ti Teow Yee, Farida Jamal, Usman Chatib Warsa, Bui Xuan Vinh, Michael R. Jacobs, Peter C. Appelbaum and Chik Hyun Pai

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 6, pages 1206-1211
Published in print June 1999 | ISSN: 1058-4838
Published online June 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514783
Spread of Drug-Resistant Streptococcus pneumoniae in Asian Countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

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Antimicrobial susceptibility of 996 isolates of Streptococcus pneumoniae from clinical specimens was investigated in 11 Asian countries from September 1996 to June 1997. Korea had the greatest frequency of nonsusceptible strains to penicillin with 79.7%, followed by Japan (65.3%), Vietnam (60.8%), Thailand (57.9%), Sri Lanka (41.2%), Taiwan (38.7%), Singapore (23.1%), Indonesia (21.0%), China (9.8%), Malaysia (9.0%), and India (3.8%). Serotypes 23F and 19F were the most common. Pulsed-field gel electrophoresis (PFGE) of 154 isolates from Asian countries showed several major PFGE patterns. The serotype 23F Spanish clone shared the same PFGE pattern with strains from Korea, Japan, Singapore, Taiwan, Thailand, and Malaysia. Fingerprinting analysis of pbp1a, pbp2x, and pbp2b genes of 12 strains from six countries also showed identical fingerprints of penicillin- binding protein genes in most strains. These data suggest the possible introduction and spread of international epidemic clones into Asian countries and the increasing problems of pneumococcal drug resistance in Asian countries for the first time.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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