Journal Article

Resistance of Streptococcus pyogenes to Erythromycin and Related Antibiotics in Italy

Giuseppe Cornaglia, Marco Ligozzi, Annarita Mazzariol, Laura Masala, Giuliana Lo Cascio and Roberta Fontana

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue Supplement_1, pages S87-S92
Published in print August 1998 | ISSN: 1058-4838
Published online August 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514908
Resistance of Streptococcus pyogenes to Erythromycin and Related Antibiotics in Italy

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A survey of antimicrobial resistance in Streptococcus pyogenes, performed within the framework of a national surveillance program, has revealed a dramatic increase in resistance of S. pyogenes to erythromycin in most areas of Italy. In virtually all the centers that provided data for 3 consecutive years, the incidence of erythromycin-resistant strains increased twofold to 20-fold from 1993 to 1995 and was greater than 30% in five of the 14 centers participating in the study. The clonality of erythromycin-resistant isolates was studied in 15 strains isolated from different patients at the Institute of Microbiology of Verona University (Verona). The features of the Verona isolates and the substantially different rates of erythromycin and clindamycin resistance observed in most centers suggest that the spread of different resistance genes in multiple clones might be occurring throughout the country.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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