Journal Article

Clonal Relationships Among High-Level Penicillin-Resistant <i>Streptococcus pneumoniae</i> in the United States

Gary V. Doern, Angela B. Brueggemann, Michael Blocker, Michael Dunne, H. Preston Holley, Karen Sue Kehl, Jen Duval, Kari Kugler, Shannon Putnam, Allan Rauch and Michael A. Pfaller

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 4, pages 757-761
Published in print October 1998 | ISSN: 1058-4838
Published online October 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514937
Clonal Relationships Among High-Level Penicillin-Resistant Streptococcus pneumoniae in the United States

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During the past 6 to 7 years, the problem of antimicrobial resistance in Streptococcus pneumoniae has grown dramatically in the United States. Currently, ∼26.5% of pneumococcal isolates express intermediate levels of resistance to penicillin; ∼17.5% are highly penicillin resistant. We studied whether clonal relationships exist among current isolates of high-level penicillin-resistant S. pneumoniae (PRSP) in the United States. One hundred forty-seven PRSP isolates recovered in a 30-center surveillance study in the United States during 1994–1995 were characterized with respect to serotype, antimicrobial susceptibility pattern, and pulsed-field gel electrophoresis (PFGE) profile. Only six serotypes were observed among the 147 PRSP isolates examined in this study: 6A, 6B, 9A, 14, 19F, and 23F. One hundred three (70.1%) of the 147 strains were characterized by one of only nine PFGE types; 76 (51.7%) of the 147 isolates were characterized by only four PFGE profiles. Currently in the United States, most PRSP strains are represented by relatively few clonal groups.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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