Journal Article

Effect of Oral <i>β</i>-Carotene Supplementation on Plasma Human Immunodeficiency Virus (HIV) RNA Levels and CD4<sup>+</sup> Cell Counts in HIV-Infected Patients

Ajani P. Nimmagadda, Betty J. Burri, T. Neidlinger, William A. O'Brien and Matthew Bidwell Goetz

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 5, pages 1311-1313
Published in print November 1998 | ISSN: 1058-4838
Published online November 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514990
Effect of Oral β-Carotene Supplementation on Plasma Human Immunodeficiency Virus (HIV) RNA Levels and CD4+ Cell Counts in HIV-Infected Patients

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We conducted a pilot, open-label study to assess the effect of short-term β-carotene administration (180 mg/d with meals for 4 weeks) on the plasma human immunodeficiency virus (HIV) RNA levels and CD4+ lymphocyte counts in 21 HIV-infected patients. We found that plasma HIV RNA levels and CD4+ lymphocyte counts did not change following this short course of β-carotene supplementation. Patients with lower serum concentrations of β-carotene before supplementation were no more likely to have an increase in their CD4+ lymphocyte count or plasma HIV RNA copy number than were those with higher concentrations. No correlation was found between pre- or postsupplementation β-carotene or vitamin A concentrations and pre- or postsupplementation CD4+ lymphocyte counts or plasma HIV RNA titers. This study provides no support for β-carotene supplementation for HIV-infected subjects with normal baseline serum levels of β-carotene and vitamin A.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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