Journal Article

Risk Factors for Prosthetic Joint Infection: Case-Control Study

Elie F. Berbari, Arlen D. Hanssen, Mary C. Duffy, James M. Steckelberg, Duane M. Ilstrup, William S. Harmsen and Douglas R. Osmon

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 5, pages 1247-1254
Published in print November 1998 | ISSN: 1058-4838
Published online November 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/514991
Risk Factors for Prosthetic Joint Infection: Case-Control Study

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We conducted a matched case-control study to determine risk factors for the development of prosthetic joint infection. Cases were patients with prosthetic hip or knee joint infection. Controls were patients who underwent total hip or knee arthroplasty and did not develop prosthetic joint infection. A multiple logistic regression model indicated that risk factors for prosthetic joint infection were the development of a surgical site infection not involving the prosthesis (odds ratio [OR], 35.9; 95% confidence interval [CI], 8.3–154.6), a National Nosocomial Infections Surveillance (NNIS) System surgical patient risk index score of 1 (OR, 1.7; 95% CI, 1.2–2.3) or 2 (OR, 3.9; 95% CI, 2.0–7.5), the presence of a malignancy (OR, 3.1; 95% CI, 1.3–7.2), and a history of joint arthroplasty (OR, 2.0; 95% CI, 1.4–3.0). Our findings suggest that a surgical site infection not involving the joint prosthesis, an NNIS System surgical patient risk index score of 1 or 2, the presence of a malignancy, and a history of a joint arthroplasty are associated with an increased risk of prosthetic joint infection.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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