Journal Article

Serotype Distribution and Prevalence of Resistance to Benzylpenicillin in Three Representative Populations of <i>Streptococcus pneumoniae</i> Isolates from the Coast of Kenya

J. A. G. Scott, A. J. Hall, A. Hannington, R. Edwards, S. Mwarumba, B. Lowe, D. Griffiths, D. Crook and K. Marsh

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 6, pages 1442-1450
Published in print December 1998 | ISSN: 1058-4838
Published online December 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515013
Serotype Distribution and Prevalence of Resistance to Benzylpenicillin in Three Representative Populations of Streptococcus pneumoniae Isolates from the Coast of Kenya

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As surveillance data from sub-Saharan Africa are few, three representative populations of Streptococcus pneumoniae isolates were examined in Kenya for serotype distribution and Etest minimum inhibitory concentrations (MICs) of benzylpenicillin: (1) 75 lung aspirate or blood culture isolates from 301 consecutive adult patients with pneumonia, (2) 112 invasive isolates from continuous pediatric inpatient surveillance over 4 years, and (3) 97 nasopharyngeal isolates from systematically selected sick children. The proportions with benzylpenicillin MICs of ⩾0.1 µg/mL were 0.27, 0.29, and 0.47, respectively. Vaccine-related serotypes accounted for 96% of invasive isolates from children and 90% of those from human immunodeficiency virus (HIV)-seropositive adults. Serotype 1 accounted for 44% of pneumococci from HIV-seronegative patients but only 5% of those from HIV-seropositive patients (P = .0002). Of serotype 1 isolates, 98% were susceptible to benzylpenicillin, but serogroups 13, 14, 19, and 23 were strongly associated with an MIC of ⩾0.1 mg/mL.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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