Journal Article

Fatal Pancarditis Associated with Human Granulocytic Ehrlichiosis in a 44-Year-Old Man

Arshad Jahangir, Chris Kolbert, William Edwards, Paul Mitchell, J. Stephen Dumler and David H. Persing

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 6, pages 1424-1427
Published in print December 1998 | ISSN: 1058-4838
Published online December 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515014
Fatal Pancarditis Associated with Human Granulocytic Ehrlichiosis in a 44-Year-Old Man

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Human cases of infection with a granulocytotropic Ehrlichia species closely related to Ehrlichia equi are now being described with increasing frequency in the United States, especially in areas where Lyme disease is already endemic. We describe a case of fatal pancarditis during the course of human granulocytic ehrlichiosis (HGE) in a 44-year-old outdoor worker who was previously treated for presumptive Lyme disease. Serological and molecular diagnostic tests for Borrelia burgdorferi and Babesia microti infections were negative. Postmortem serum specimens were seroreactive for HGE, and molecular evidence of infection with the HGE agent was obtained. These findings suggest that carditis may be a manifestation of HGE, further complicating the differential diagnosis of tick-borne illness.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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