Journal Article

IgG Responses to Protein-Conjugated Pneumococcal Capsular Polysaccharides in Persons Who Are Genetically Incapable of Responding to Unconjugated Polysaccharides

Daniel M. Musher, Jean E. Groover, David A. Watson, Maria C. Rodriguez Barradas and Robert E. Baughn

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 27, issue 6, pages 1487-1490
Published in print December 1998 | ISSN: 1058-4838
Published online December 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515039
IgG Responses to Protein-Conjugated Pneumococcal Capsular Polysaccharides in Persons Who Are Genetically Incapable of Responding to Unconjugated Polysaccharides

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We have previously shown that the capacity to make IgG to pneumococcal capsular polysaccharides (PCPs) is inherited as an autosomal, mixed codominant trait. The purpose of this study was to determine whether this genetically determined unresponsiveness could be overcome by injection of protein-conjugated pneumococcal vaccines. Seven healthy adults who had failed to produce IgG to five or more of 10 representative PCPs after receiving pneumococcal vaccine and whose parents, siblings, and/or offspring had a similar lack of responsiveness received a series of protein-conjugated polysaccharide vaccines. Excellent IgG responses to most of the PCPs tested were eventually observed in five of the seven subjects after they received octavalent diphtheria toxoid-conjugated vaccine. Administration of certain protein-conjugated PCPs leads to IgG responses in some persons who lack the capacity to respond to unconjugated PCPs.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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