Journal Article

Molecular Epidemiology of Gram-Negative Bacteremia

Constanze Wendt, Shawn A. Messer, Richard J. Hollis, Michael A. Pfaller, Richard P. Wenzel and Loreen A. Herwaldt

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 3, pages 605-610
Published in print March 1999 | ISSN: 1058-4838
Published online March 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515151
Molecular Epidemiology of Gram-Negative Bacteremia

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We did pulsed field gel electrophoresis (PFGE) and antibiotic susceptibility testing on 202 gramnegative isolates obtained from blood cultures between 1 January 1989 and 31 December 1993. Seventy-eight patients had at least two gram-negative isolates of the same species recovered from blood drawn one or more days apart and met the other study criteria. Twenty patients had only 1 bloodstream infection, 48 patients had 1 recurrence of bacteremia, and 10 patients had >1 recurrence of bacteremia. Of 80 recurrences of bacteremia, 52 (65%) were relapses and 28 (35%) were reinfections. Seventy-eight percent of the episodes of bacteremia occurring ⩽300 days apart were relapses, and 100% occurring >300 days apart were reinfections (P < .001). Organisms causing recurrent bacteremia were not more resistant than those causing initial episodes. In conclusion, most episodes of recurrent gram-negative bacteremia were relapses. Relapses and reinfections could not be distinguished only by the length of time between episodes or by antimicrobial susceptibility patterns.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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