Journal Article

Sustained Anabolic Effects of Long-Term Androgen Administration in Men with AIDS Wasting

Steven Grinspoon, Colleen Corcoran, Ellen Anderson, Jane Hubbard, Takara Stanley, Nesli Basgoz and Anne Klibanski

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 3, pages 634-636
Published in print March 1999 | ISSN: 1058-4838
Published online March 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515162
Sustained Anabolic Effects of Long-Term Androgen Administration in Men with AIDS Wasting

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Fifty-one human immunodeficiency virus-positive men with hypogonadism and wasting were randomized to receive testosterone enanthate, 300 mg im every 3 weeks, or placebo for 6 months, followed by open-label testosterone administration for 6 months. Subjects initially randomized to placebo gained lean body mass (LBM) only after crossover to testosterone administration (mean change ± standard error of the mean, −0.6 ± 0.7 kg [months 0–6] vs. 1.9 ± 0.7 kg [months 6–12]; P = .03). In contrast, subjects initially randomized to testosterone continued to gain LBM during open-label administration (2.0 ± 0.7 kg [months 0–6] vs. 1.6 ± 0.6 kg [months 6–12]; P = .62) and had gained more LBM at 1 year than did subjects receiving testosterone for only the final 6 months of the study (3.7 ± 0.8 kg vs. 1.0 ± 1.0 kg; P = .05). Testosterone administration results in sustained increases in LBM during 1 year of therapy in hypogonadal men with AIDS wasting.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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