Journal Article

Endotoxin Interactions with Lipopolysaccharide-Responsive Cells

Peter S. Tobias, Richard I. Tapping and Julie A. Gegner

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 3, pages 476-481
Published in print March 1999 | ISSN: 1058-4838
Published online March 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515163
Endotoxin Interactions with Lipopolysaccharide-Responsive Cells

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Recent work has identified two proteins that work together to enable many cell types to respond to endotoxin. These two proteins, lipopolysaccharide (LPS) binding protein (LBP) and CD14, also participate in cellular internalization of endotoxin, which may occur independently of cellular activation. Current work with antibodies to LBP and CD14 as well as “knockout” mice in the context of LPS-initiated endotoxic shock suggests that inhibition of this pathway could be therapeutically useful. These observations point to the need to identify new molecules that mediate LPSinitiated transmembrane signaling and internalization of LPS-protein complexes.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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