Journal Article

Guide to Major Clinical Trials of Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients: Protease Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, and Nucleotide Reverse Transcriptase Inhibitors

Jorge A. Tavel, Kirk D. Miller and Henry Masur

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 3, pages 643-676
Published in print March 1999 | ISSN: 1058-4838
Published online March 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515179
Guide to Major Clinical Trials of Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients: Protease Inhibitors, Non-Nucleoside Reverse Transcriptase Inhibitors, and Nucleotide Reverse Transcriptase Inhibitors

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In this AIDS Commentary, Drs. Tavel, Miller, and Masur of the National Institutes of Health present this compilation of clinical trials of antiretroviral therapy in HIV-infected patients, which complements two similar reviews published as AIDS Commentaries in Clinical Infectious Diseases (1995;20:1145–51 and 1996;23:15–27). Whereas the previous compilations focused on trials of nucleoside analogues, this review is based on published articles and abstracts of clinical trials of protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and nucleotide reverse transcriptase inhibitors in HIV-infected patients. The intent is to present a thorough, but not necessarily exhaustive, review of studies that have shaped our principles of antiretroviral therapy. Preference is given to clinical endpoint trials, proof-of-concept trials that have influenced the standard of care for HIV treatment, double-blind, randomized trials, and large trials with long-term patient followup. Smaller trials that address important questions are also included.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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