Journal Article

Antigen Presentation in the Immune Response to Infectious Diseases

Eric G. Pamer

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 28, issue 4, pages 714-716
Published in print April 1999 | ISSN: 1058-4838
Published online April 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/515207
Antigen Presentation in the Immune Response to Infectious Diseases

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T lymphocytes mediate immune defenses against infectious diseases. The major histocompatibility complex class I and class II antigen-processing pathways play an essential role in the activation of pathogen-specific T lymphocytes by presenting peptide fragments derived from pathogen-encoded proteins. The past 5 years have seen remarkable advances in our understanding of both of these antigen-processing pathways. Many new proteins that are critical to T-cell-mediated defenses against infectious pathogens have been identified and characterized. Although the direct effects of aging on antigen processing and presentation are relatively unexplored, it is likely that immunosenescence affects and is affected by the antigen-processing pathways.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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